• World Efforts against covid-19

    THIS SITE WILL ONLY DISPLAY NEWS AND LINKS FROM CREDIBLE SOURCES

    With so much misinformation on social media sites like Facebook and platforms like WhatsApp - we have developed a site only quoting credible sources.

     

    We will only focus on advancements the world is making in the fight to overcome this enemy.

     

    For information on Covid-19 and how to protect yourself please refer to the WHO website below and your country's health agency.

     

    https://www.who.int/emergencies/diseases/novel-coronavirus-2019

     

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  • Latest news

    from around the world

    The main read is the Vaccines, Research & Treatments sections

  • Where we are with the most promising vaccines

    Vaccine testing stages - correct as of 30.1.20 - note: this list represents my own, unscientific, opinion on the vaccines I think are the most promising

    I am also only looking at UK/US/EU for EUA and general release

    1

    Pre-CLINICAL

    Testing of vaccine in non-human subjects

     

     

     

     

     

     

     

     

     

    1Positive Phase III data

    2Revised results

    3UK/US EUA requested

    4UK/US EUA granted!

    5General release!

    2

    Phase I

    Testing of vaccine on small group of healthy volunteers

    • Inovio
    • CureVac
    • Imperial College London
    3

    Phase I/II

    Testing of vaccine on c100–300 patients to assess efficacy and side effects

    • Sanofi and GlaxoSmithKline
    4

    Phase II/III

    Testing of vaccine on a larger group of patients (c300–3000+) to assess efficacy and side effects

    • BioNTech and Pfizer - 94% efficacy1,2,3
    • Moderna - 94.5% efficacy1,3
    • Oxford/AstraZeneca - 70% efficacy potentially 90%1,3
    • Sinovac
    • China National Biotec
    • Johnson & Johnson (Janssen Pharmaceutical)
    • CanSino Biologics
    5

    Phase IV

    Vaccine can be released Testing and monitoring will continue

    Emergency Use Authorisation (EUA) to be announced soon

  • Most Promising Vaccines

    What types of vaccines are they?

    RNA-BASED

    Moderna

    BioNTech and - Pfizer

    Imperial College

    CureVac

    Similar to DNA vaccines, these experimental vaccines provide immunity through introduction of genetic material (RNA). RNA vaccines can also be potentially developed more quickly and easily than other vaccines.

     

    No RNA vaccines have been approved for human use but clinical trials have been carried out or are ongoing on mRNA vaccines for influenza, cytomegalovirus, HIV-1, rabies and Zika virus

    Non-Replicating Viral Vector

    Oxford/AstraZeneca

    CanSino Biologics

    Johnson & Johnson

    Similar to replicating viral vector vaccines -a viral gene is added to a different, non-replicating, virus and delivered to the vaccine recipient.

     

    The first adenovirus vaccine for any disease was approved for Ebola in June 2020.

    INACTIVATED VIRUS

    Sinovac

    China National -Biotec

    A vaccine consisting of the disease-causing virus that has been killed, with heat or chemicals, so it won’t make you sick.

     

    Examples of inactive virus vaccines:

    inactivated poliovirus (IPV) vaccine, whole cell pertussis (whooping cough) vaccine, rabies vaccine and the hepatitis A virus vaccine

    PROTEIN SUBUNIT

     

    Sanofi/

    GlaxoSmithKline

    Rather than introducing whole viruses to an immune system, a fragment of the virus is used to trigger an immune response and stimulate immunity.

     

    Examples of Protein Subunit vaccines: Diphtheria, tetanus, pertussis, hepatitis B

    DNA Based

    Inovio

    DNA-based vaccines work by inserting a genetically engineered blueprint of viral gene(s) into small DNA molecules (called plasmids) for injection into vaccinated people.Cells take in the DNA plasmids and follow their instructions to build viral proteins, which the immune system recognises as foreign, triggers a immune response that protects against the disease.

     

    No DNA vaccines have been approved for human use to date

  • Vaccine, Research & Treatments

    LAST 30 UPDATES rolling information on world advances

    NOTE: AS WE ONLY REPORT ON ADVANCES AFTER THEY HAVE BEEN VERIFIED BY MULTIPLE, HIGHLY CREDIBLE, NEWS OUTLETS, THE DATES BELOW MAY BE ONE OR TWO DAYS AFTER the ACTUAL EVENT

    1

    30th November 2020

    Moderna to submit application for EUA in US, EU and UK

    2

    27th November 2020

    UK Medicines and Healthcare products Regulatory Agency (MHRA) to review Oxford/AstraZeneca vaccine

    3

    23rd November 2020

    BREAKING NEWS:

    Oxford/AstraZeneca vaccine shows average efficacy of 70%

    4

    20th November 2020

    Pfizer to submit application to US regulators for emergency use of its Covid-19 vaccine

    5

    20th November 2020

    Arthritis drug may treat severe Covid-19 cases

    6

    18th November 2020

    Further Pfizer/BioNTech trial data shows vaccine to be even more effective than first reported

    7

    18th November 2020

    Sinovac's Covid-19 vaccine shows promise in mid-stage trials

    8

    17th November 2020

    Early research, in Lab conditions, shows that Mouthwash can kill virus in 30 seconds

    9

    17th November 2020

    FDA grant Inovio permission to begin Phase II trials

    10

    16th November 2020

    BREAKING NEWS: Moderna Covid vaccine candidate shows almost 95% efficacy rate

    11

    10th November 2020

    Eli Lilly receives authorisation for its antibody treatment

    12

    9th November 2020

    BREAKING NEWS: Pfizer/BioNtech vaccine offers 90% efficacy

    13

    5th November 2020

    Oxford and AstraZeneca both state that results should be available this year

    14

    3rd November 2020

    CureVac's covid-19 vaccine shows immune response in early trials

    15

    1st November 2020

    India's Bharat Biotech to start phase III trials in November

    16

    29th October 2020

    Moderna says it is gearing up for global launch

    17

    27th October 2020

    Oxford University/AstraZeneca vaccine shows strong immune response in all ages

    18

    22nd October 2020

    Moderna completes enrolment in large COVID-19 vaccine study

    19

    20th October 2020

    UK to begin "challenge" vaccine trials

    20

    9th October 2020

    Remdesivir final data shows it reduces recovery time

    21

    29th September 2020

    Early safety study of Moderna's vaccine shows signs of it working well in older adults

    22

    26th September 2020

    Johnson and Johnson vaccine produced strong immune response in early stage trials

    23

    25th September 2020

    Novavax starts Phase III Covid-19 vaccine trial in UK

    24

    23rd September 2020

    Johnson & Johnsons' Janssen Pharmaceutical moves to phase III

    25

    15th September 2020

    Clinical study to explore the effects of delivering vaccines by inhalation to take place

    26

    13th September 2020

    Oxford/AstraZeneca resumes vaccine trials after 4 day pause

    27

    9th September 2020

    Oxford/AstraZeneca vaccine trial put on hold - do not read into this too much

    28

    3rd September 2020

    Sanofi & GSK move to phase 1/2 trials of their covid-19 vaccine candidate

    29

    2nd September 2020

    Cheap steroid drugs, like hydrocortisone, reduces deaths in the sickest COVID-19 patients

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